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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50439298
Substrate
n/a
Meas. Tech.
ChEMBL_977567 (CHEMBL2423349)
IC50
83±n/a nM
Citation
 Dragovich, PS; Bair, KW; Baumeister, T; Ho, YC; Liederer, BM; Liu, X; Liu, Y; O'Brien, T; Oeh, J; Sampath, D; Skelton, N; Wang, L; Wang, W; Wu, H; Xiao, Y; Yuen, PW; Zak, M; Zhang, L; Zheng, X Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 23:4875-85 (2013) [PubMed]  Article 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM50439298
Synonyms:
CHEMBL2419522 | US10696692, Example 265
Type:
Small organic molecule
Emp. Form.:
C22H26N4O4S
Mol. Mass.:
442.531
SMILES:
CC(=O)N1CCC(CC1)S(=O)(=O)c1ccc(CNC(=O)N2Cc3ccncc3C2)cc1
Structure:
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