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Target
Casein kinase I isoform epsilon
Ligand
BDBM50439435
Substrate
n/a
Meas. Tech.
ChEMBL_977606 (CHEMBL2423573)
IC50
305±n/a nM
Citation
 Mente, S; Arnold, E; Butler, T; Chakrapani, S; Chandrasekaran, R; Cherry, K; DiRico, K; Doran, A; Fisher, K; Galatsis, P; Green, M; Hayward, M; Humphrey, J; Knafels, J; Li, J; Liu, S; Marconi, M; McDonald, S; Ohren, J; Paradis, V; Sneed, B; Walton, K; Wager, T Ligand-protein interactions of selective casein kinase 1d inhibitors. J Med Chem 56:6819-28 (2013) [PubMed]  Article 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM50439435
Synonyms:
CHEMBL2420700
Type:
Small organic molecule
Emp. Form.:
C15H12FN3
Mol. Mass.:
253.2743
SMILES:
Cn1cc(c(n1)-c1ccc(F)cc1)-c1ccncc1
Structure:
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