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Target
Peptidyl-prolyl cis-trans isomerase A
Ligand
BDBM50440299
Substrate
n/a
Meas. Tech.
ChEMBL_982571 (CHEMBL2428216)
Ki
12±n/a nM
Citation
 Malesevic, M; Gutknecht, D; Prell, E; Klein, C; Schumann, M; Nowak, RA; Simon, JC; Schiene-Fischer, C; Saalbach, A Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147. J Med Chem 56:7302-11 (2013) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase A
Synonyms:
CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:
Protein
Mol. Mass.:
18015.32
Organism:
Homo sapiens (Human)
Description:
P62937
Residue:
165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
  
Inhibitor
Name:
BDBM50440299
Synonyms:
CHEMBL2424823
Type:
Small organic molecule
Emp. Form.:
C67H113N13O12
Mol. Mass.:
1292.694
SMILES:
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)Cc2nc3ccc(C)cc3[nH]2)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |r|
Structure:
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