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Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Ligand
BDBM50440627
Substrate
n/a
Meas. Tech.
ChEMBL_983601 (CHEMBL2427113)
IC50
90000±n/a nM
Citation
 Belluti, F; Perozzo, R; Lauciello, L; Colizzi, F; Kostrewa, D; Bisi, A; Gobbi, S; Rampa, A; Bolognesi, ML; Recanatini, M; Brun, R; Scapozza, L; Cavalli, A Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem 56:7516-26 (2013) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Synonyms:
Fatty acid synthase
Type:
PROTEIN
Mol. Mass.:
26222.50
Organism:
Plasmodium falciparum
Description:
ChEMBL_983601
Residue:
230
Sequence:
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDVSSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
  
Inhibitor
Name:
BDBM50440627
Synonyms:
CHEMBL2426553
Type:
Small organic molecule
Emp. Form.:
C15H9ClO6
Mol. Mass.:
320.681
SMILES:
Oc1cc(O)c2cc(Oc3ccc(Cl)cc3O)c(=O)oc2c1
Structure:
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