Reaction Details Report a problem with these data
Target
Heme oxygenase 1
Ligand
BDBM50441450
Substrate
n/a
Meas. Tech.
ChEMBL_988012 (CHEMBL2438670)
IC50
>100000±n/a nM
Citation
 Vlahakis, JZ; Vukomanovic, D; Nakatsu, K; Szarek, WA Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position. Bioorg Med Chem 21:6788-95 (2013) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50441450
Synonyms:
CHEMBL2436266
Type:
Small organic molecule
Emp. Form.:
C19H19Cl2N3
Mol. Mass.:
360.28
SMILES:
Clc1cc(Cl)cc(Cn2c(CN3CCCC3)nc3ccccc23)c1
Structure:
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