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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50240612
Substrate
n/a
Meas. Tech.
ChEMBL_1276665 (CHEMBL3089097)
Ki
4810±n/a nM
Citation
 Yang, S; Li, X; Hu, F; Li, Y; Yang, Y; Yan, J; Kuang, C; Yang, Q Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem 56:8321-31 (2013) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50240612
Synonyms:
CHEMBL306946 | GNF-PF-2691 | Indolo[2,1-b]quinazoline-6,12-dione | TCMDC-125859 | TRYPTANTHRIN | US10669273, Compound 5a
Type:
Small organic molecule
Emp. Form.:
C15H8N2O2
Mol. Mass.:
248.2362
SMILES:
O=C1c2ccccc2-n2c1nc1ccccc1c2=O
Structure:
Search PDB for entries with ligand similarity: