Reaction Details Report a problem with these data
Target
Prolyl hydroxylase EGLN3
Ligand
BDBM50446882
Substrate
n/a
Meas. Tech.
ChEMBL_1290489 (CHEMBL3119780)
EC50
400±n/a nM
Citation
 Rabinowitz, MH Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. J Med Chem 56:9369-402 (2014) [PubMed]  Article 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM50446882
Synonyms:
CHEMBL3115284
Type:
Small organic molecule
Emp. Form.:
C24H24ClN3O5
Mol. Mass.:
469.917
SMILES:
CC(C)(C)c1ccc(Cn2nc(c(O)c(C(=O)NCC(O)=O)c2=O)-c2ccc(Cl)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: