Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM51526
Substrate
n/a
Meas. Tech.
ChEMBL_1289425 (CHEMBL3116921)
IC50
38000±n/a nM
Citation
Dragovich, PS; Zhao, G; Baumeister, T; Bravo, B; Giannetti, AM; Ho, YC; Hua, R; Li, G; Liang, X; Ma, X; O'Brien, T; Oh, A; Skelton, NJ; Wang, C; Wang, W; Wang, Y; Xiao, Y; Yuen, PW; Zak, M; Zhao, Q; Zheng, X Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett 24:954-62 (2014) [PubMed] Article
More Info.:
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
Inhibitor
Name:
BDBM51526
Synonyms:
6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-methyl-1-benzopyran-2-one | 6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-methyl-coumarin | 6-[(dimethylamino)methyl]-4-ethyl-7-hydroxy-8-methylchromen-2-one | 6-[(dimethylamino)methyl]-4-ethyl-8-methyl-7-oxidanyl-chromen-2-one | MLS000042532 | SMR000048671 | cid_5390086
Type:
Small organic molecule
Emp. Form.:
C15H19NO3
Mol. Mass.:
261.3163
SMILES:
CCc1cc(=O)oc2c(C)c(O)c(CN(C)C)cc12