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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50448450
Substrate
n/a
Meas. Tech.
ChEMBL_1297282 (CHEMBL3132068)
Kd
0.080000±n/a nM
Citation
 Caillé, F; Morley, TJ; Tavares, AA; Papin, C; Twardy, NM; Alagille, D; Lee, HS; Baldwin, RM; Seibyl, JP; Barret, O; Tamagnan, GD Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699. Bioorg Med Chem Lett 23:6243-7 (2013) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-hydroxytryptamine receptor 4 protein | Serotonin 4 (5-HT4) receptor
Type:
PROTEIN
Mol. Mass.:
45024.02
Organism:
Sus scrofa
Description:
ChEMBL_1297282
Residue:
402
Sequence:
MDKLDANGSSKEGFGSVEKVVLLTFVSAVILMAVLGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDVWIYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRVAVLLAGCWAIPVLISFLPIMQGWNNIGITDLERTSKPRLGQDLHVIEKRKFHQNSNSTYCIFMVNKPYAITCSVVAFYIPFLLMVLAYWRIYVTAKEHAHQIQMLQRAGAPAEGRPPSADQHSTHRMRTETKAAKTLCVIMGCFCLCWAPFFVTNVVDPFADYSVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPCVAGQTVPCSTTTVNGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM50448450
Synonyms:
CHEMBL3126112
Type:
Small organic molecule
Emp. Form.:
C16H21ClN2O4
Mol. Mass.:
340.802
SMILES:
CN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1
Structure:
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