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Target
Aromatic-L-amino-acid decarboxylase
Ligand
BDBM50000060
Substrate
n/a
Meas. Tech.
ChEMBL_1333664 (CHEMBL3231050)
IC50
10000±n/a nM
Citation
 Rudd, EA; Cunningham, WC; Thanassi, JW Coenzyme--substrate adducts as inhibitors of mouse liver 3,4-dihydroxyphenylalanine decarboxylase. J Med Chem 22:233-7 (1979) [PubMed]  Article 
Target
Name:
Aromatic-L-amino-acid decarboxylase
Synonyms:
DDC_MOUSE | DOPA decarboxylase | Ddc
Type:
PROTEIN
Mol. Mass.:
53874.00
Organism:
Mus musculus
Description:
ChEMBL_1333664
Residue:
480
Sequence:
MDSREFRRRGKEMVDYIADYLDGIEGRPVYPDVEPGYLRPLIPATAPQEPETYEDIIKDIEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAARTKVIRQLQAASPEFTQAAIMEKLVAYTSDQAHSSVERAGLIGGIKLKAVPSDGNFSMRASALREALERDKAAGLIPFFVVATLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKRRTDLTGAFNMDPVYLKHSHQDSGFITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVELSHEFESLVRQDPRFEICTEVILGLVCFRLKGSNELNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCARTVESAHVQLAWEHISDLASSVLRAEKE
  
Inhibitor
Name:
BDBM50000060
Synonyms:
CHEMBL3228258
Type:
Small organic molecule
Emp. Form.:
C17H21N2O9P
Mol. Mass.:
428.3304
SMILES:
Cc1ncc(COP(O)(O)=O)c(CN[C@@H](Cc2ccc(O)c(O)c2)C(O)=O)c1O |r|
Structure:
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