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Target
Prolyl endopeptidase
Ligand
BDBM50005870
Substrate
n/a
Meas. Tech.
ChEMBL_1336164 (CHEMBL3241124)
IC50
3.1±n/a nM
Citation
 Kallinen, A; Todorov, B; Kallionpää, R; Bäck, S; Sarparanta, M; Raki, M; García-Horsman, JA; Bergström, KA; Wallén, EA; Männistö, PT; Airaksinen, AJ Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo. Eur J Med Chem 79:436-45 (2014) [PubMed]  Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | PPCE_MOUSE | Pep | Post-proline cleaving enzyme | Prep
Type:
PROTEIN
Mol. Mass.:
80738.55
Organism:
Mus musculus
Description:
ChEMBL_1336164
Residue:
710
Sequence:
MLSFQYPDVYRDETSVQEYHGHKICDPYSWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTKEELEPMVFREVTVKGIDAADYQTIQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDTKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIEWIQ
  
Inhibitor
Name:
BDBM50005870
Synonyms:
CHEMBL3236271
Type:
Small organic molecule
Emp. Form.:
C20H29N3O2
Mol. Mass.:
342.4639
SMILES:
[11CH3]Nc1ccc(CCCC(=O)N2CCC[C@H]2C(=O)N2CCCC2)cc1 |r|
Structure:
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