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Target
Integrase
Ligand
BDBM50009453
Substrate
n/a
Meas. Tech.
ChEMBL_1336402 (CHEMBL3242251)
IC50
140±n/a nM
Citation
 Ferro, S; De Luca, L; Lo Surdo, G; Morreale, F; Christ, F; Debyser, Z; Gitto, R; Chimirri, A A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition. Bioorg Med Chem 22:2269-79 (2014) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50009453
Synonyms:
CHEMBL259011 | CHI-1043
Type:
Small organic molecule
Emp. Form.:
C20H16FNO5
Mol. Mass.:
369.3431
SMILES:
COc1cccc2n(Cc3ccc(F)cc3)cc(C(=O)\C=C(/O)C(O)=O)c12
Structure:
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