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Target
Proteasome subunit beta type-8
Ligand
BDBM50010987
Substrate
n/a
Meas. Tech.
ChEMBL_1351341 (CHEMBL3266190)
Ki
3500±n/a nM
Citation
 Fan, H; Angelo, NG; Warren, JD; Nathan, CF; Lin, G Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome. ACS Med Chem Lett 5:405-10 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50010987
Synonyms:
CHEMBL3259880
Type:
Small organic molecule
Emp. Form.:
C19H17N3O4S
Mol. Mass.:
383.421
SMILES:
CC(=O)N[C@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)-c1nsc(=O)o1 |r|
Structure:
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