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Target
Neutral cholesterol ester hydrolase 1
Ligand
BDBM50012157
Substrate
n/a
Meas. Tech.
ChEMBL_1352949 (CHEMBL3269816)
IC50
>100000±n/a nM
Citation
 Duncan, KK; Otrubova, K; Boger, DL a-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain. Bioorg Med Chem 22:2763-70 (2014) [PubMed]  Article 
Target
Name:
Neutral cholesterol ester hydrolase 1
Synonyms:
Aadacl1 | Arylacetamide deacetylase-like 1 | CPO-BP | Chlorpyrifos oxon-binding protein | Kiaa1363 | NCEH | NCEH1_MOUSE | Nceh1 | Neutral cholesterol ester hydrolase
Type:
Single-pass type II membrane protein; hydrolase
Mol. Mass.:
45742.11
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant KIAA1363 transiently transfected in COS-7 cells.
Residue:
408
Sequence:
MRSSCVLLAALLALAAYYVYIPLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLNHHLIALNFIITSFGKQSARSSPKVKVTDTDFDGVEVRVFEGSPKPEEPLRRSVIYIHGGGWALASAKISYYDQLCTTMAEELNAVIVSIEYRLVPQVYFPEQIHDVIRATKYFLQPEVLDKYKVDPGRVGISGDSAGGNLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNTPSYQQSMNTPILPRHVMVRYWLDYFKGNYDFVEAMIVNNHTSLDVERAAALRARLDWTSLLPSSIKKNYKPIMQTTGNARIVQEIPQLLDAAASPLIAEQEVLEALPKTYILTCEHDVLRDDGIMYAKRLESAGVNVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
  
Inhibitor
Name:
BDBM50012157
Synonyms:
CHEMBL3264462
Type:
Small organic molecule
Emp. Form.:
C24H18N2O4
Mol. Mass.:
398.4107
SMILES:
O=C(C1CCc2cc(Oc3ccccc3)ccc2O1)c1ncc(o1)-c1ccccn1
Structure:
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