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Target
Arylamine N-acetyltransferase 1
Ligand
BDBM50014987
Substrate
n/a
Meas. Tech.
ChEMBL_1347886 (CHEMBL3267122)
IC50
5800±n/a nM
Citation
 Egleton, JE; Thinnes, CC; Seden, PT; Laurieri, N; Lee, SP; Hadavizadeh, KS; Measures, AR; Jones, AM; Thompson, S; Varney, A; Wynne, GM; Ryan, A; Sim, E; Russell, AJ Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1. Bioorg Med Chem 22:3030-54 (2014) [PubMed]  Article 
Target
Name:
Arylamine N-acetyltransferase 1
Synonyms:
AAC1 | ARY1_HUMAN | NAT1
Type:
PROTEIN
Mol. Mass.:
33898.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1347886
Residue:
290
Sequence:
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
  
Inhibitor
Name:
BDBM50014987
Synonyms:
CHEMBL3262087
Type:
Small organic molecule
Emp. Form.:
C25H22N2O4S
Mol. Mass.:
446.518
SMILES:
CN(C1=C(Nc2cc(C)cc(C)c2)C(=O)c2ccccc2C1=O)S(=O)(=O)c1ccccc1 |c:2|
Structure:
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