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Target
Delta-aminolevulinic acid dehydratase
Ligand
BDBM50017186
Substrate
n/a
Meas. Tech.
ChEMBL_1365623 (CHEMBL3297470)
IC50
500000±n/a nM
Citation
 Lentz, CS; Halls, VS; Hannam, JS; Strassel, S; Lawrence, SH; Jaffe, EK; Famulok, M; Hoerauf, A; Pfarr, KM wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs. J Med Chem 57:2498-510 (2014) [PubMed]  Article 
Target
Name:
Delta-aminolevulinic acid dehydratase
Synonyms:
ALAD | ALADH | HEM2_HUMAN | Porphobilinogen synthase
Type:
PROTEIN
Mol. Mass.:
36296.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1365623
Residue:
330
Sequence:
MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE
  
Inhibitor
Name:
BDBM50017186
Synonyms:
CHEMBL3287362
Type:
Small organic molecule
Emp. Form.:
C23H18F3N3O3S
Mol. Mass.:
473.468
SMILES:
OC(=O)c1cccc2nc(CCNC(=O)c3cccs3)n(Cc3cccc(c3)C(F)(F)F)c12
Structure:
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