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Target
Aromatic-L-amino-acid decarboxylase
Ligand
BDBM25525
Substrate
n/a
Meas. Tech.
ChEMBL_1363990 (CHEMBL3295577)
IC50
200000±n/a nM
Citation
 Cheng, P; Zhou, J; Qing, Z; Kang, W; Liu, S; Liu, W; Xie, H; Zeng, J Synthesis of 5-methyl phenanthridium derivatives: a new class of human DOPA decarboxylase inhibitors. Bioorg Med Chem Lett 24:2712-6 (2014) [PubMed]  Article 
Target
Name:
Aromatic-L-amino-acid decarboxylase
Synonyms:
AADC | DDC | DDC_HUMAN
Type:
PROTEIN
Mol. Mass.:
53931.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_83
Residue:
480
Sequence:
MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
  
Inhibitor
Name:
BDBM25525
Synonyms:
24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium | CHEMBL490129 | Pseudochelerythrine | Veadent | cid_5154 | sanguinarine | sangvinarin
Type:
Small organic molecule
Emp. Form.:
C20H14NO4
Mol. Mass.:
332.3289
SMILES:
C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Structure:
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