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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50018006
Substrate
n/a
Meas. Tech.
ChEMBL_1366444 (CHEMBL3296344)
IC50
88±n/a nM
Citation
 Deng, X; Kokkonda, S; El Mazouni, F; White, J; Burrows, JN; Kaminsky, W; Charman, SA; Matthews, D; Rathod, PK; Phillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem 57:5381-94 (2014) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE
Type:
PROTEIN
Mol. Mass.:
42711.08
Organism:
Mus musculus
Description:
ChEMBL_1366444
Residue:
395
Sequence:
MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
  
Inhibitor
Name:
BDBM50018006
Synonyms:
CHEMBL3289672 | US9238653, Table 5, Compound 49
Type:
Small organic molecule
Emp. Form.:
C14H7F8N5
Mol. Mass.:
397.2261
SMILES:
Cc1cc(Nc2cc(F)c(c(F)c2)C(F)(F)F)n2nc(nc2n1)C(F)(F)F
Structure:
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