Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-7
Ligand
BDBM50007208
Substrate
n/a
Meas. Tech.
ChEMBL_1362841 (CHEMBL3295791)
IC50
29±n/a nM
Citation
 Kawamura, S; Unno, Y; Asai, A; Arisawa, M; Shuto, S Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones. Bioorg Med Chem 22:3091-5 (2014) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-7
Synonyms:
Macropain chain Z | Multicatalytic endopeptidase complex chain Z | PSB7_HUMAN | PSMB7 | Proteasome subunit Z | Z
Type:
PROTEIN
Mol. Mass.:
29968.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
277
Sequence:
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
  
Inhibitor
Name:
BDBM50007208
Synonyms:
CHEMBL3237861
Type:
Small organic molecule
Emp. Form.:
C27H35NO5
Mol. Mass.:
453.5705
SMILES:
[H][C@]1([C@@H](C)CC)[C@@H](OC1=O)C(=O)NCCC(COCc1ccccc1)COCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: