Reaction Details Report a problem with these data
Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50019142
Substrate
n/a
Meas. Tech.
ChEMBL_1361815 (CHEMBL3292751)
IC50
6220±n/a nM
Citation
 Fu, HJ; Zhou, YR; Bao, BH; Jia, MX; Zhao, Y; Zhang, L; Li, JX; He, HL; Zhou, XM Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. J Med Chem 57:4692-709 (2014) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH1_RAT | Tph | Tph1 | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
51069.51
Organism:
Rattus norvegicus
Description:
ChEMBL_1361815
Residue:
444
Sequence:
MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV
  
Inhibitor
Name:
BDBM50019142
Synonyms:
CHEMBL3288777
Type:
Small organic molecule
Emp. Form.:
C40H55N3O3
Mol. Mass.:
625.883
SMILES:
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(=O)NCC(=O)OCC)[C@@]1(C)Cc1nc3ccccc3nc1C2(C)C |r,t:9|
Structure:
Search PDB for entries with ligand similarity: