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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50020716
Substrate
n/a
Meas. Tech.
ChEMBL_1363438 (CHEMBL3295827)
IC50
360±n/a nM
Citation
 Gomha, SM; Eldebss, TM; Abdulla, MM; Mayhoub, AS Diphenylpyrroles: Novel p53 activators. Eur J Med Chem 82:472-9 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50020716
Synonyms:
CHEMBL3286447
Type:
Small organic molecule
Emp. Form.:
C27H20N4
Mol. Mass.:
400.4745
SMILES:
Cc1[nH]c(c(c1-c1ccnc2nc3ccccc3n12)-c1ccccc1)-c1ccccc1 |(23.91,-24.16,;22.42,-23.76,;21.24,-24.74,;19.94,-23.91,;20.33,-22.42,;21.86,-22.33,;22.7,-21.04,;21.99,-19.67,;22.82,-18.37,;24.36,-18.44,;25.07,-19.81,;26.56,-20.2,;26.64,-21.74,;27.85,-22.7,;27.62,-24.22,;26.18,-24.78,;24.98,-23.82,;25.21,-22.3,;24.24,-21.11,;19.35,-21.23,;19.89,-19.78,;18.92,-18.6,;17.4,-18.85,;16.85,-20.28,;17.83,-21.47,;18.5,-24.47,;17.3,-23.51,;15.86,-24.07,;15.63,-25.59,;16.84,-26.55,;18.27,-25.99,)|
Structure:
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