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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50020717
Substrate
n/a
Meas. Tech.
ChEMBL_1363438 (CHEMBL3295827)
IC50
440±n/a nM
Citation
 Gomha, SM; Eldebss, TM; Abdulla, MM; Mayhoub, AS Diphenylpyrroles: Novel p53 activators. Eur J Med Chem 82:472-9 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50020717
Synonyms:
CHEMBL3291433
Type:
Small organic molecule
Emp. Form.:
C24H18N4OS
Mol. Mass.:
410.491
SMILES:
Cc1[nH]c(c(c1-c1ccnc2[nH]c(=S)[nH]c(=O)c12)-c1ccccc1)-c1ccccc1 |(21.9,-22.75,;20.41,-22.34,;19.21,-23.29,;17.93,-22.44,;18.34,-20.96,;19.87,-20.89,;20.72,-19.61,;19.79,-18.37,;20.44,-16.96,;21.96,-16.79,;22.88,-18.03,;24.4,-17.85,;25.32,-19.09,;26.84,-18.92,;24.69,-20.5,;23.17,-20.67,;22.8,-22.17,;22.24,-19.43,;17.38,-19.76,;17.95,-18.32,;16.99,-17.11,;15.46,-17.35,;14.9,-18.78,;15.85,-19.98,;16.48,-22.98,;15.29,-22,;13.85,-22.54,;13.6,-24.06,;14.78,-25.04,;16.22,-24.5,)|
Structure:
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