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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50020725
Substrate
n/a
Meas. Tech.
ChEMBL_1363438 (CHEMBL3295827)
IC50
260±n/a nM
Citation
 Gomha, SM; Eldebss, TM; Abdulla, MM; Mayhoub, AS Diphenylpyrroles: Novel p53 activators. Eur J Med Chem 82:472-9 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50020725
Synonyms:
CHEMBL3291439
Type:
Small organic molecule
Emp. Form.:
C32H34Cl2N4O4
Mol. Mass.:
609.543
SMILES:
COc1ccc(-c2nc(c(-c3ccc(Cl)cc3)n2C(=O)N2CCN(CCO)CC2)-c2ccc(Cl)cc2)c(OC(C)C)c1
Structure:
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