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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50020727
Substrate
n/a
Meas. Tech.
ChEMBL_1363438 (CHEMBL3295827)
IC50
910±n/a nM
Citation
 Gomha, SM; Eldebss, TM; Abdulla, MM; Mayhoub, AS Diphenylpyrroles: Novel p53 activators. Eur J Med Chem 82:472-9 (2014) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM50020727
Synonyms:
CHEMBL3291220
Type:
Small organic molecule
Emp. Form.:
C24H17N5
Mol. Mass.:
375.4253
SMILES:
Cc1[nH]c(c(c1-c1ccnc2c(cnn12)C#N)-c1ccccc1)-c1ccccc1 |(17.11,-21.51,;15.65,-21.02,;14.4,-21.91,;13.16,-20.99,;13.65,-19.53,;15.19,-19.55,;16.1,-18.31,;15.49,-16.9,;16.41,-15.66,;17.94,-15.83,;18.55,-17.25,;20.01,-17.73,;20,-19.27,;18.53,-19.74,;17.63,-18.49,;21.27,-16.84,;22.52,-15.94,;12.75,-18.28,;13.4,-16.88,;12.5,-15.63,;10.97,-15.78,;10.33,-17.17,;11.22,-18.43,;11.69,-21.46,;10.56,-20.42,;9.09,-20.88,;8.75,-22.39,;9.89,-23.42,;11.36,-22.96,)|
Structure:
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