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Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50021387
Substrate
n/a
Meas. Tech.
ChEMBL_1362706 (CHEMBL3294687)
IC50
10965±n/a nM
Citation
 Kowalczyk, P; Salat, K; Höfner, GC; Mucha, M; Rapacz, A; Podkowa, A; Filipek, B; Wanner, KT; Kulig, K Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides. Eur J Med Chem 83:256-73 (2014) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13
Type:
PROTEIN
Mol. Mass.:
68283.40
Organism:
Mus musculus
Description:
ChEMBL_1460089
Residue:
602
Sequence:
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
  
Inhibitor
Name:
BDBM50021387
Synonyms:
CHEMBL3289585
Type:
Small organic molecule
Emp. Form.:
C29H34ClN3O
Mol. Mass.:
476.053
SMILES:
NCCC(N1CCC(CC1)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccccc1Cl
Structure:
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