Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM33410
Substrate
n/a
Meas. Tech.
ChEMBL_1364716 (CHEMBL3293758)
IC50
>5000000±n/a nM
Citation
 Velthuisen, EJ; Johns, BA; Gerondelis, P; Chen, Y; Li, M; Mou, K; Zhang, W; Seal, JW; Hightower, KE; Miranda, SR; Brown, K; Leesnitzer, L Pyridopyrimidinone inhibitors of HIV-1 RNase H. Eur J Med Chem 83:609-16 (2014) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM33410
Synonyms:
CHEMBL16755 | N-hydroxyisoquinolinedione, 2
Type:
Small organic molecule
Emp. Form.:
C9H7NO3
Mol. Mass.:
177.1568
SMILES:
ON1C(=O)Cc2ccccc2C1=O
Structure:
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