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Target
Cyclin-dependent kinase 2
Ligand
BDBM50021717
Substrate
n/a
Meas. Tech.
ChEMBL_1368656
IC50
16±n/a nM
Citation
 Blake, JF; Gaudino, JJ; De Meese, J; Mohr, P; Chicarelli, M; Tian, H; Garrey, R; Thomas, A; Siedem, CS; Welch, MB; Kolakowski, G; Kaus, R; Burkard, M; Martinson, M; Chen, H; Dean, B; Dudley, DA; Gould, SE; Pacheco, P; Shahidi-Latham, S; Wang, W; West, K; Yin, J; Moffat, J; Schwarz, JB Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorg Med Chem Lett 24:2635-9 (2014) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50021717
Synonyms:
CHEMBL3298414
Type:
Small organic molecule
Emp. Form.:
C21H25ClFN5O3
Mol. Mass.:
449.906
SMILES:
OC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(F)c(Cl)c1 |r|
Structure:
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