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Target
Beta-3 adrenergic receptor
Ligand
BDBM86453
Substrate
n/a
Meas. Tech.
ChEMBL_1369178
EC50
25±n/a nM
Citation
 McKinnell, RM; Klein, U; Linsell, MS; Moran, EJ; Nodwell, MB; Pfeiffer, JW; Thomas, GR; Yu, C; Jacobsen, JR Discovery of TD-4306, a long-actingß2-agonist for the treatment of asthma and COPD. Bioorg Med Chem Lett 24:2871-6 (2014) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM86453
Synonyms:
CAS_73573-87-2 | Formoterol | NSC_3083544
Type:
Small organic molecule
Emp. Form.:
C19H24N2O4
Mol. Mass.:
344.4049
SMILES:
COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1
Structure:
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