Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50024563
Substrate
n/a
Meas. Tech.
ChEMBL_1438093 (CHEMBL3387894)
Kd
0.460000±n/a nM
Citation
 Romagnoli, R; Baraldi, PG; IJzerman, AP; Massink, A; Cruz-Lopez, O; Lopez-Cara, LC; Saponaro, G; Preti, D; Aghazadeh Tabrizi, M; Baraldi, S; Moorman, AR; Vincenzi, F; Borea, PA; Varani, K Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene. J Med Chem 57:7673-86 (2014) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50024563
Synonyms:
CHEMBL3330574
Type:
Small organic molecule
Emp. Form.:
C24H22ClNOS
Mol. Mass.:
407.956
SMILES:
CC(C)(C)Cc1c(sc(N)c1C(=O)c1ccc(Cl)cc1)C#Cc1ccccc1
Structure:
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