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Target
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Ligand
BDBM50027699
Substrate
n/a
Meas. Tech.
ChEMBL_1435384 (CHEMBL3383458)
Ki
46±n/a nM
Citation
 Ferla, S; Gomaa, MS; Brancale, A; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation. Eur J Med Chem 87:39-51 (2014) [PubMed]  Article 
Target
Name:
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:
25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | Calcidiol 1-monooxygenase | Cyp27b | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase | CP27B_MOUSE | Cyp27b1 | Cyp27b | Cyp40
Type:
PROTEIN
Mol. Mass.:
56238.51
Organism:
Mouse
Description:
ChEMBL_109473
Residue:
507
Sequence:
MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERSINLQFVDR
  
Inhibitor
Name:
BDBM50027699
Synonyms:
CHEMBL3344396
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: