Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 2
Ligand
BDBM50033089
Substrate
n/a
Meas. Tech.
ChEMBL_1432711 (CHEMBL3390515)
IC50
0.620000±n/a nM
Citation
 Itadani, S; Takahashi, S; Ima, M; Sekiguchi, T; Fujita, M; Nakayama, Y; Takeuchi, J Discovery of Highly Potent Dual CysLT1 and CysLT2 Antagonist. ACS Med Chem Lett 5:1230-4 (2014) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 2
Synonyms:
CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39657.52
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:
346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
  
Inhibitor
Name:
BDBM50033089
Synonyms:
CHEMBL3342959
Type:
Small organic molecule
Emp. Form.:
C31H34N2O7
Mol. Mass.:
546.6109
SMILES:
OC(=O)CCCN1CC(Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc12)C(O)=O
Structure:
Search PDB for entries with ligand similarity: