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Target
Cathepsin B
Ligand
BDBM50033397
Substrate
n/a
Meas. Tech.
ChEMBL_1434318 (CHEMBL3386422)
IC50
29000±n/a nM
Citation
 Thomas, AA; Hunt, KW; Newhouse, B; Watts, RJ; Liu, X; Vigers, G; Smith, D; Rhodes, SP; Brown, KD; Otten, JN; Burkard, M; Cox, AA; Geck Do, MK; Dutcher, D; Rana, S; DeLisle, RK; Regal, K; Wright, AD; Groneberg, R; Liao, J; Scearce-Levie, K; Siu, M; Purkey, HE; Lyssikatos, JP 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors. J Med Chem 57:10112-29 (2014) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50033397
Synonyms:
CHEMBL3357667
Type:
Small organic molecule
Emp. Form.:
C21H20ClFN2O3
Mol. Mass.:
402.847
SMILES:
[H][C@]12OCCC[C@]1(C)Oc1ccc(cc1[C@@]21COC(N)=N1)-c1cc(F)cc(Cl)c1 |r,c:22|
Structure:
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