Reaction Details Report a problem with these data
Target
Falcipain 2
Ligand
BDBM50033669
Substrate
n/a
Meas. Tech.
ChEMBL_1435072 (CHEMBL3388289)
IC50
>50000±n/a nM
Citation
Conroy, T; Guo, JT; Elias, N; Cergol, KM; Gut, J; Legac, J; Khatoon, L; Liu, Y; McGowan, S; Rosenthal, PJ; Hunt, NH; Payne, RJ Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem 57:10557-63 (2014) [PubMed] Article
More Info.:
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
Inhibitor
Name:
BDBM50033669
Synonyms:
CHEMBL3358139
Type:
Small organic molecule
Emp. Form.:
C41H70F3N7O11
Mol. Mass.:
894.03
SMILES:
[O-]C(=O)C(F)(F)F.CC[C@H](C)[C@H]([NH+](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)N1C[C@@H](O)C[C@H]1C(=O)OC |r|