Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50439491
Substrate
n/a
Meas. Tech.
ChEMBL_1434457 (CHEMBL3388274)
IC50
38900±n/a nM
Citation
 Zwick, V; Chatzivasileiou, AO; Deschamps, N; Roussaki, M; Simões-Pires, CA; Nurisso, A; Denis, I; Blanquart, C; Martinet, N; Carrupt, PA; Detsi, A; Cuendet, M Aurones as histone deacetylase inhibitors: identification of key features. Bioorg Med Chem Lett 24:5497-501 (2015) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50439491
Synonyms:
AUREUSIDIN
Type:
Small organic molecule
Emp. Form.:
C15H10O6
Mol. Mass.:
286.2363
SMILES:
Oc1cc2O\C(=C/c3ccc(O)c(O)c3)C(=O)c2c(O)c1
Structure:
Search PDB for entries with ligand similarity: