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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM98990
Substrate
n/a
Meas. Tech.
ChEMBL_1437289 (CHEMBL3384792)
IC50
1170±n/a nM
Citation
 Rzasa, RM; Frohn, MJ; Andrews, KL; Chmait, S; Chen, N; Clarine, JG; Davis, C; Eastwood, HA; Horne, DB; Hu, E; Jones, AD; Kaller, MR; Kunz, RK; Miller, S; Monenschein, H; Nguyen, T; Pickrell, AJ; Porter, A; Reichelt, A; Zhao, X; Treanor, JJ; Allen, JR Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorg Med Chem 22:6570-85 (2015) [PubMed]  Article 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM98990
Synonyms:
US8497265, 446
Type:
Small organic molecule
Emp. Form.:
C24H19N7O
Mol. Mass.:
421.454
SMILES:
Nc1ncc2cc(ccc2n1)-c1nccnc1OC1CN(C1)c1ccc2ccccc2n1
Structure:
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