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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50041527
Substrate
n/a
Meas. Tech.
ChEMBL_1443974 (CHEMBL3375362)
IC50
57000±n/a nM
Citation
 Sakai, T; Matsumoto, Y; Ishikawa, M; Sugita, K; Hashimoto, Y; Wakai, N; Kitao, A; Morishita, E; Toyoshima, C; Hayashi, T; Akiyama, T Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. Bioorg Med Chem 23:328-39 (2015) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50041527
Synonyms:
CHEMBL3358389
Type:
Small organic molecule
Emp. Form.:
C19H14N4O
Mol. Mass.:
314.3407
SMILES:
O=C(Nc1nc[nH]n1)c1cccc(c1)-c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: