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Target
Transient receptor potential cation channel subfamily M member 8
Ligand
BDBM50044108
Substrate
n/a
Meas. Tech.
ChEMBL_1452555 (CHEMBL3363422)
IC50
19000±n/a nM
Citation
 Terada, Y; Kitajima, M; Taguchi, F; Takayama, H; Horie, S; Watanabe, T Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives. J Nat Prod 77:1831-8 (2014) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily M member 8
Synonyms:
LTrpC-6 | Long transient receptor potential channel 6 | Ltrpc6 | TRPM8_MOUSE | Transient receptor potential p8 | Trp-p8 | Trpm8 | Trpp8
Type:
PROTEIN
Mol. Mass.:
127713.99
Organism:
Mus musculus
Description:
ChEMBL_107992
Residue:
1104
Sequence:
MSFEGARLSMRSRRNGTMGSTRTLYSSVSRSTDVSYSDSDLVNFIQANFKKRECVFFTRDSKAMENICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRSCDDEGHFSAQYIMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFKCCCKEKNMESNACCFRNEDNETLAWEGVMKENYLVKINTKANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
  
Inhibitor
Name:
BDBM50044108
Synonyms:
CHEMBL3325768
Type:
Small organic molecule
Emp. Form.:
C21H28N2O2
Mol. Mass.:
340.4592
SMILES:
[H][C@]12C[C@H](CC)[C@]3([H])N(C1)CCc1c([nH]c4ccc(OC)cc14)[C@]3(CO)C2 |r,TLB:4:3:23.26:8.9,24:23:8.9:3.2,THB:13:23:8.9:3.2,3:6:26.9.1:13.12.11.10,10:8:23.26:3.2|
Structure:
Search PDB for entries with ligand similarity: