Reaction Details
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Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Ligand
BDBM50044551
Substrate
n/a
Meas. Tech.
ChEMBL_1457994 (CHEMBL3367168)
Kd
<60±n/a nM
Citation
Sweeney, ZK; Fu, J; Wiedmann, B From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds. J Med Chem 57:7145-59 (2014) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Synonyms:
CYP3 | CyP-D | CyP-M | Cyclophilin D | Cyclophilin F | CypD | Mitochondrial cyclophilin | PPIF | PPIF_HUMAN | PPIase F | Rotamase F
Type:
PROTEIN
Mol. Mass.:
22052.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109465
Residue:
207
Sequence:
MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDVVKKIESFGSKSGRTSKKIVITDCGQLS
Inhibitor
Name:
BDBM50044551
Synonyms:
CHEMBL3327189
Type:
Small organic molecule
Emp. Form.:
C68H121N11O12
Mol. Mass.:
1284.7548
SMILES:
[H][C@@]1([#6@H](-[#8])-[#6@H](-[#6])-[#6]\[#6]=[#6]\[#6])[#7](-[#6])-[#6](=O)-[#6@H](-[#6](-[#6])-[#6])-[#7](-[#6])-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7](-[#6])-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7](-[#6])-[#6](=O)-[#6@@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7](-[#6])-[#6](=O)-[#6@H](-[#6](-[#6])-[#6])-[#7](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7](-[#6])-[#6](=O)-[#6@H](-[#6])-[#7](-[#6])-[#6](=O)-[#6@H](-[#6]-[#6])-[#7]-[#6]1=O |r|
Structure:
