Reaction Details Report a problem with these data
Target
Subtilisin-like protease 1
Ligand
BDBM50045202
Substrate
n/a
Meas. Tech.
ChEMBL_1458077 (CHEMBL3367640)
IC50
5000±n/a nM
Citation
Giovani, S; Penzo, M; Brogi, S; Brindisi, M; Gemma, S; Novellino, E; Savini, L; Blackman, MJ; Campiani, G; Butini, S Rational design of the first difluorostatone-based PfSUB1 inhibitors. Bioorg Med Chem Lett 24:3582-6 (2014) [PubMed] Article
More Info.:
Target
Name:
Subtilisin-like protease 1
Synonyms:
SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1
Type:
PROTEIN
Mol. Mass.:
77866.88
Organism:
Plasmodium falciparum
Description:
ChEMBL_830092
Residue:
690
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
Inhibitor
Name:
BDBM50045202
Synonyms:
CHEMBL3310709
Type:
Small organic molecule
Emp. Form.:
C50H65F2N7O12
Mol. Mass.:
994.0876
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)OCc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)C(F)(F)C(=O)NCC(=O)OCc1ccccc1 |r|