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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50048253
Substrate
n/a
Meas. Tech.
ChEMBL_1456413 (CHEMBL3368862)
IC50
4900±n/a nM
Citation
 Porter, DW; Bradley, M; Brown, Z; Charlton, SJ; Cox, B; Hunt, P; Janus, D; Lewis, S; Oakley, P; O'Connor, D; Reilly, J; Smith, N; Press, NJ The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg Med Chem Lett 24:3285-90 (2014) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50048253
Synonyms:
CHEMBL3310781
Type:
Small organic molecule
Emp. Form.:
C17H15F2N3OS
Mol. Mass.:
347.382
SMILES:
Oc1nc(SCc2cccc(F)c2F)nc(C2CCCC2)c1C#N
Structure:
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