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Target
Beta-2 adrenergic receptor
Ligand
BDBM86453
Substrate
n/a
Meas. Tech.
ChEMBL_1449717 (CHEMBL3378140)
IC50
0.400000±n/a nM
Citation
 Arnold, N; Beattie, D; Bradley, M; Brearley, A; Brown, L; Charlton, SJ; Fairhurst, RA; Farr, D; Fozard, J; Fullerton, J; Gosling, M; Hatto, J; Janus, D; Jones, D; Jordan, L; Lewis, C; Maas, J; McCarthy, C; Mercer, M; Oakman, H; Press, N; Profit, R; Schuerch, F; Sykes, D; Taylor, RJ; Trifilieff, A; Tuffnell, A The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-actingß2-adrenoceptor agonist. Bioorg Med Chem Lett 24:4341-7 (2014) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_CAVPO | Adrb2 | adrenergic Beta2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46993.24
Organism:
GUINEA PIG
Description:
adrenergic Beta2 ADRB2 GUINEA PIG::Q8K4Z4
Residue:
418
Sequence:
MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
  
Inhibitor
Name:
BDBM86453
Synonyms:
CAS_73573-87-2 | Formoterol | NSC_3083544
Type:
Small organic molecule
Emp. Form.:
C19H24N2O4
Mol. Mass.:
344.4049
SMILES:
COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1
Structure:
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