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Target
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Ligand
BDBM50056951
Substrate
n/a
Meas. Tech.
ChEMBL_1455848 (CHEMBL3362302)
Ki
3900±n/a nM
Citation
 Amiable, C; Paoletti, J; Haouz, A; Padilla, A; Labesse, G; Kaminski, PA; Pochet, S 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities. Eur J Med Chem 85:418-37 (2014) [PubMed]  Article 
Target
Name:
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Synonyms:
DNPH1_RAT | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) D69N | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) E93Q | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) S117A | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) Y13F | Dnph1 | Rcl | c-Myc-responsive protein Rcl
Type:
Enzyme
Mol. Mass.:
17775.23
Organism:
Rattus norvegicus (Rat)
Description:
O35820
Residue:
163
Sequence:
MAASGEQAPCSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQDLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLPQKTASSSHPSA
  
Inhibitor
Name:
BDBM50056951
Synonyms:
CHEMBL3331378
Type:
Small organic molecule
Emp. Form.:
C15H15BrN5O7P
Mol. Mass.:
488.187
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(ncnc12)-c1cncc(Br)c1 |r|
Structure:
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