Reaction Details Report a problem with these data
Target
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Ligand
BDBM50056966
Substrate
n/a
Meas. Tech.
ChEMBL_1455848 (CHEMBL3362302)
Ki
4800±n/a nM
Citation
 Amiable, C; Paoletti, J; Haouz, A; Padilla, A; Labesse, G; Kaminski, PA; Pochet, S 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities. Eur J Med Chem 85:418-37 (2014) [PubMed]  Article 
Target
Name:
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Synonyms:
DNPH1_RAT | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) D69N | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) E93Q | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) S117A | Deoxyribonucleoside 5'-monophosphate N-glycosidase (Rcl) Y13F | Dnph1 | Rcl | c-Myc-responsive protein Rcl
Type:
Enzyme
Mol. Mass.:
17775.23
Organism:
Rattus norvegicus (Rat)
Description:
O35820
Residue:
163
Sequence:
MAASGEQAPCSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQDLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLPQKTASSSHPSA
  
Inhibitor
Name:
BDBM50056966
Synonyms:
CHEMBL3331367
Type:
Small organic molecule
Emp. Form.:
C18H19N4O9P
Mol. Mass.:
466.3386
SMILES:
COC(=O)c1cccc(c1)-c1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: