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Target
Phosphomannomutase 2
Ligand
BDBM46620
Substrate
n/a
Meas. Tech.
ChEMBL_1448920 (CHEMBL3375687)
IC50
>10000±n/a nM
Citation
 Bravo, Y; Teriete, P; Dhanya, RP; Dahl, R; Lee, PS; Kiffer-Moreira, T; Ganji, SR; Sergienko, E; Smith, LH; Farquharson, C; Millán, JL; Cosford, ND Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorg Med Chem Lett 24:4308-11 (2014) [PubMed]  Article 
Target
Name:
Phosphomannomutase 2
Synonyms:
PMM2 | PMM2_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28082.33
Organism:
Homo sapiens (Human)
Description:
gi_4557839
Residue:
246
Sequence:
MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS
  
Inhibitor
Name:
BDBM46620
Synonyms:
6-fluoranyl-2-(4-methoxyphenyl)-1,2-benzothiazol-3-one | 6-fluoro-2-(4-methoxyphenyl)-1,2-benzothiazol-3-one | MLS-0315772.0001 | cid_1519965
Type:
Small organic molecule
Emp. Form.:
C14H10FNO2S
Mol. Mass.:
275.298
SMILES:
COc1ccc(cc1)-n1sc2cc(F)ccc2c1=O
Structure:
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