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Target
Probable G-protein coupled receptor 88
Ligand
BDBM50065714
Substrate
n/a
Meas. Tech.
ChEMBL_1464732 (CHEMBL3407083)
EC50
1300±n/a nM
Citation
 Bi, Y; Dzierba, CD; Fink, C; Garcia, Y; Green, M; Han, J; Kwon, S; Kumi, G; Liang, Z; Liu, Y; Qiao, Y; Zhang, Y; Zipp, G; Burford, N; Ferrante, M; Bertekap, R; Lewis, M; Cacace, A; Westphal, RS; Kimball, D; Bronson, JJ; Macor, JE The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders. Bioorg Med Chem Lett 25:1443-7 (2015) [PubMed]  Article 
Target
Name:
Probable G-protein coupled receptor 88
Synonyms:
GPR88 | GPR88_HUMAN | Probable G-protein coupled receptor 88 | STRG | Striatum-specific G-protein coupled receptor
Type:
PROTEIN
Mol. Mass.:
40264.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109566
Residue:
384
Sequence:
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
  
Inhibitor
Name:
BDBM50065714
Synonyms:
CHEMBL3400235
Type:
Small organic molecule
Emp. Form.:
C26H31N3OS
Mol. Mass.:
433.609
SMILES:
CC[C@H](C)[C@H](N)CN(C(=O)[C@@H]1C[C@H]1c1ncc(C)s1)c1ccc(cc1)-c1ccccc1 |r|
Structure:
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