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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM16661
Substrate
n/a
Meas. Tech.
ChEMBL_1464325 (CHEMBL3404592)
IC50
1130±n/a nM
Citation
 Al-Rashida, M; Ejaz, SA; Ali, S; Shaukat, A; Hamayoun, M; Ahmed, M; Iqbal, J Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies. Bioorg Med Chem 23:2435-44 (2015) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN
Type:
Protein
Mol. Mass.:
57094.82
Organism:
Bos taurus (Cattle)
Description:
P19111
Residue:
533
Sequence:
MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLGDGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLCGVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDASVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQDHTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKANELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYALGGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHIMAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
  
Inhibitor
Name:
BDBM16661
Synonyms:
1-N-(4-fluorobenzene)benzene-1,4-disulfonamide | aromatic sulfonamide compound 26
Type:
Small organic molecule
Emp. Form.:
C12H11FN2O4S2
Mol. Mass.:
330.355
SMILES:
NS(=O)(=O)c1ccc(NS(=O)(=O)c2ccc(F)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: