Target
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Ligand
BDBM50072960
Substrate
n/a
Meas. Tech.
ChEMBL_1467809 (CHEMBL3412385)
IC50
42990±n/a nM
Citation
 Cersosimo, USgorbissa, AFoti, CDrioli, SAngelica, RTomasella, APicco, RSemrau, MSStorici, PBenedetti, FBerti, FBrancolini, C Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent. J Med Chem 58:1691-704 (2015) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Synonyms:
CGI-70 | UCH-L5 | UCH37 | UCHL5 | UCHL5_HUMAN | Ubiquitin C-terminal hydrolase UCH37 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Ubiquitin thioesterase L5
Type:
PROTEIN
Mol. Mass.:
37597.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109575
Residue:
329
Sequence:
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK
  
Inhibitor
Name:
BDBM50072960
Synonyms:
CHEMBL3410537
Type:
Small organic molecule
Emp. Form.:
C20H16N2O6
Mol. Mass.:
380.3508
SMILES:
OC1C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)\C(C1)=C\c1ccc(cc1)[N+]([O-])=O
Structure:
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