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Target
Histone acetyltransferase GCN5
Ligand
BDBM47034
Substrate
n/a
Meas. Tech.
ChEMBL_1473888 (CHEMBL3419139)
IC50
2400±n/a nM
Citation
 Dahlin, JL; Nissink, JW; Strasser, JM; Francis, S; Higgins, L; Zhou, H; Zhang, Z; Walters, MA PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. J Med Chem 58:2091-113 (2015) [PubMed]  Article 
Target
Name:
Histone acetyltransferase GCN5
Synonyms:
ADA4 | ADA4 | GCN5 | GCN5_YEAST | Histone acetyltransferase GCN5 | SWI9
Type:
PROTEIN
Mol. Mass.:
51069.24
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_100832
Residue:
439
Sequence:
MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETERIGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAISSTEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGYIKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNIKPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEEVPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRLEKFFNNKVKEIPEYSHLID
  
Inhibitor
Name:
BDBM47034
Synonyms:
2,3-diphenyl-N-(phenylmethyl)-1,2,4-thiadiazol-2-ium-5-amine;hydrobromide | MLS-0390886.0001 | N-benzyl-2,3-diphenyl-1,2,4-thiadiazol-2-ium-5-amine;hydrobromide | benzyl-(2,3-diphenyl-1,2,4-thiadiazol-2-ium-5-yl)amine;hydrobromide | cid_25181255
Type:
Small organic molecule
Emp. Form.:
C21H18N3S
Mol. Mass.:
344.452
SMILES:
C(Nc1nc(-c2ccccc2)[n+](s1)-c1ccccc1)c1ccccc1
Structure:
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