Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50079356
Substrate
n/a
Meas. Tech.
ChEMBL_1470464 (CHEMBL3419181)
IC50
154±n/a nM
Citation
 Li, X; Ma, S Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ. Eur J Med Chem 95:1-15 (2015) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50079356
Synonyms:
CHEMBL511201
Type:
Small organic molecule
Emp. Form.:
C14H8ClF2N3O2S
Mol. Mass.:
355.747
SMILES:
NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F
Structure:
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