Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50079359
Substrate
n/a
Meas. Tech.
ChEMBL_1470448 (CHEMBL3418982)
IC50
12300±n/a nM
Citation
 Li, X; Ma, S Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ. Eur J Med Chem 95:1-15 (2015) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_ECOLI | ftsZ | sfiB | sulB
Type:
Protein
Mol. Mass.:
40305.83
Organism:
Escherichia coli
Description:
P0A9A6
Residue:
383
Sequence:
MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD
  
Inhibitor
Name:
BDBM50079359
Synonyms:
Viriditoxin
Type:
Small organic molecule
Emp. Form.:
C34H30O14
Mol. Mass.:
662.5936
SMILES:
COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O |(-7.16,-4.87,;-5.83,-5.64,;-4.49,-4.86,;-4.49,-3.32,;-3.16,-5.63,;-1.82,-4.86,;-.49,-5.62,;.84,-4.86,;2.16,-5.62,;3.49,-4.86,;4.83,-5.63,;6.16,-4.85,;7.5,-5.62,;7.5,-7.16,;6.16,-3.3,;4.82,-2.54,;4.82,-1,;3.49,-3.31,;2.16,-2.55,;2.16,-1.01,;.84,-3.32,;-.49,-2.54,;-.49,-1,;-1.82,-3.32,;7.48,-2.53,;7.47,-1,;6.13,-.23,;6.12,1.31,;8.8,-.22,;10.14,-.98,;11.46,-.21,;12.8,-.96,;14.12,-.18,;15.47,-.94,;16.8,-.16,;18.14,-.93,;18.15,-2.47,;19.47,-.15,;20.81,-.91,;15.48,-2.49,;14.14,-3.27,;14.15,-4.81,;12.81,-2.51,;11.48,-3.28,;11.49,-4.82,;10.15,-2.52,;8.82,-3.3,;8.83,-4.84,)|
Structure:
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